After Marriage in 1942, Wu and Yuan moved to the east Coast of the USA. There, Wu became a faculty member at Smith Collage, and Wu taught about science, specifically about x-ray crystallography. In 1942 Wu moved to New Jersey, and became a faculty member at Princeton University until 1944 and also became the first female physics instructor. In the beginning of 1944 she went to Columbia University, (Located in New York City) and remained there until 1980. Throughout 1958 though, she became a full-time professor and was elected to the national academy of science. She also did research and development for the Columbia project, called the "Manhattan Project" which led to the discovery of making atomic bombs (which were used in WW2). In other words, she helped develop the first atomic bombs that were ever created. She then moved multiple times around the USA working as a teacher, member, or a Physics instructor at multiple schools.